Preparation and crystal structure of sildenafil salicylate

Publication date: January–February 2015 Source:Mendeleev Communications, Volume 25, Issue 1 Author(s): Dmitrijs Stepanovs , M?ra Jure , Anatoly Mishnev A new two-component drug solid comprising the active pharmaceutical ingredients sildenafil and salicylic acid (1:1) was prepared in the form of an addition salt and characterized by single crystal X-ray diffraction analysis. Graphical abstract (Source: Mendeleev Communications)

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Why sildenafil and sildenafil citrate monohydrate crystals are not stable?

Publication date: Available online 24 January 2015 Source:Saudi Pharmaceutical Journal Author(s): Somchai Sawatdee , Chaveng Pakawatchai , Kwanjai Nitichai , Teerapol Srichana , Hirihattaya Phetmung Sildenafil citrate was crystallized by various techniques aiming to determine the behavior and factors affecting on the crystal growth. There are only 2 types of sildenafil obtaining from crystallization: sildenafil (1) and sildenafil citrate monohydrate (2). The used techniques were (i) crystallization from saturated solutions, (ii) addition of an antisolvent, (iii) reflux and (iv) slow solvent evaporation method. By pursuing these various methods, our work pointed that the best formation of crystal (1) was obtained from technique no. (i). Surprisingly, the obtained crystals (1) was perfecte…

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Cilostazol but not sildenafil prevents memory impairment after chronic cerebral hypoperfusion in middle-aged rats.

Authors: Godinho J, Oliveira JN, Ferreira ED, Zaghi GG, Bacarin CC, Oliveira RM, Milani H Abstract We previously reported that the phosphodiesterase-5 (PDE5) inhibitor sildenafil prevented neurodegeneration but not learning deficits in middle-aged rats that were subjected to the permanent, three-stage, four-vessel occlusion/internal carotid artery (4-VO/ICA) model of chronic cerebral hypoperfusion (CCH). In the present study, we examined whether the PDE3 inhibitor cilostazol alleviates the loss of long-term memory (i.e., retrograde amnesia) caused by CCH. The effect of sildenafil was then compared to cilostazol. Naive rats (12-15 months old) were trained in a non-food-rewarded eight-arm radial maze and subjected to CCH. One week later, retrograde memory was assessed for 5 weeks. Ci…

Oral Tadalafil in Children with Pulmonary Arterial Hypertension

Conclusions: Oral tadalafil was administered easily and tolerated well and improved mean pulmonary artery pressure (MPAP) in children with PAH, which suggests that oral tadalafil may be more effective and safer than sildenafil in the treatment of PAH.[…]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Drug Research)