Why sildenafil and sildenafil citrate monohydrate crystals are not stable?

Publication date: Available online 24 January 2015 Source:Saudi Pharmaceutical Journal Author(s): Somchai Sawatdee , Chaveng Pakawatchai , Kwanjai Nitichai , Teerapol Srichana , Hirihattaya Phetmung Sildenafil citrate was crystallized by various techniques aiming to determine the behavior and factors affecting on the crystal growth. There are only 2 types of sildenafil obtaining from crystallization: sildenafil (1) and sildenafil citrate monohydrate (2). The used techniques were (i) crystallization from saturated solutions, (ii) addition of an antisolvent, (iii) reflux and (iv) slow solvent evaporation method. By pursuing these various methods, our work pointed that the best formation of crystal (1) was obtained from technique no. (i). Surprisingly, the obtained crystals (1) was perfecte…

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